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. 1993 Feb;422(5):536-8.
doi: 10.1007/BF00375084.

Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre

E Benoit  1 , D Escande
Affiliations

Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre

E Benoit et al. Pflugers Arch. 1993 Feb.

Abstract

The effects of 1-500 microM riluzole, a novel psychotropic agent, were studied on the nodal K current of isolated nerve fibres of the frog. When added to the external solution, the substance rapidly and reversibly inhibited slow, fast 1 and fast 2 K components of the tail K current. The concentrations of riluzole inducing half maximum reduction of slow, fast 1 and fast 2 K conductances were 413 microM, 24 microM and 21 microM respectively. It is concluded that the substance is about 20 times more effective in blocking fast than slow K channels.

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References

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