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. 1993 Apr 15;90(8):3408-12.
doi: 10.1073/pnas.90.8.3408.

Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes

C F Voliva  1 , S Tsang, B M Peterlin
Affiliations

Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes

C F Voliva et al. Proc Natl Acad Sci U S A. .

Abstract

Defects in promoters of the nonexpressed DQA2, DQB2, and DOB genes from the class II major histo-compatibility complex were mapped by placing Z and X boxes of these silent genes into a synthetic DRA promoter. These conserved upstream sequences confer B-cell-specific and gamma-interferon-inducible expression to the DRA gene. Since DRA promoters containing the X box from the DQA2 gene and Z boxes from DQA2, DQB2, and DOB genes were neither expressed constitutively in B cells nor inducible by gamma interferon in fibroblastic cells, these conserved upstream sequences are implicated in the transcriptional defects of these silent genes.

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