Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Apr 15;90(8):3408-12.
doi: 10.1073/pnas.90.8.3408.

Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes

C F Voliva  1 , S Tsang, B M Peterlin
Affiliations

Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes

C F Voliva et al. Proc Natl Acad Sci U S A. .

Abstract

Defects in promoters of the nonexpressed DQA2, DQB2, and DOB genes from the class II major histo-compatibility complex were mapped by placing Z and X boxes of these silent genes into a synthetic DRA promoter. These conserved upstream sequences confer B-cell-specific and gamma-interferon-inducible expression to the DRA gene. Since DRA promoters containing the X box from the DQA2 gene and Z boxes from DQA2, DQB2, and DOB genes were neither expressed constitutively in B cells nor inducible by gamma interferon in fibroblastic cells, these conserved upstream sequences are implicated in the transcriptional defects of these silent genes.

PubMed Disclaimer

References

    1. J Biol Chem. 1987 Jun 25;262(18):8759-66 - PubMed
    1. J Biol Chem. 1987 Jun 25;262(18):8748-58 - PubMed
    1. Immunogenetics. 1987;26(1-2):63-73 - PubMed
    1. Annu Rev Biochem. 1988;57:991-1028 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8598-602 - PubMed

Publication types

MeSH terms

LinkOut - more resources