Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Apr;36(4):335-7.
doi: 10.1007/BF00400237.

Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism

M Stoffel  1 , R Espinosa 3rd, S R Keller, G E Lienhard, M M Le Beau, G I Bell
Affiliations

Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism

M Stoffel et al. Diabetologia. 1993 Apr.

Abstract

The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (non-insulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in order to study the role of genetic variation in this gene in the pathogenesis of diabetes mellitus. As a first step in these studies, we have mapped the IRS-1 gene to chromosome 2, bands q35-q36.1 and identified a simple tandem repeat DNA polymorphism in this gene that will be useful for genetic studies.

PubMed Disclaimer

References

    1. J Clin Endocrinol Metab. 1991 Dec;73(6):1158-63 - PubMed
    1. J Clin Invest. 1991 Oct;88(4):1323-30 - PubMed
    1. Diabetes. 1991 Dec;40(12):1712-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9358-62 - PubMed
    1. Nature. 1991 Jul 4;352(6330):73-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources