Comment on

• Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.

  Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D. Gale NW, et al. Nature. 1993 May 6;363(6424):88-92. doi: 10.1038/363088a0. Nature. 1993. PMID: 8386805
• Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

  Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Egan SE, et al. Nature. 1993 May 6;363(6424):45-51. doi: 10.1038/363045a0. Nature. 1993. PMID: 8479536
• The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

  Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D. Rozakis-Adcock M, et al. Nature. 1993 May 6;363(6424):83-5. doi: 10.1038/363083a0. Nature. 1993. PMID: 8479540
• Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

  Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J. Li N, et al. Nature. 1993 May 6;363(6424):85-8. doi: 10.1038/363085a0. Nature. 1993. PMID: 8479541