Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Apr 11;21(7):1523-5.
doi: 10.1093/nar/21.7.1523.

Editing of a tRNA anticodon in marsupial mitochondria changes its codon recognition

A Janke  1 , S Pääbo
Affiliations
Free PMC article

Editing of a tRNA anticodon in marsupial mitochondria changes its codon recognition

A Janke et al. Nucleic Acids Res. .
Free PMC article

Abstract

RNA editing has been described for organellar genes of protozoa and plants as well as in three cases for nuclear transcripts of mammals. The mitochondrial tRNA for aspartic acid is encoded in the mitochondrial genome of marsupials with the anticodon GCC. However, cDNA from the gene product revealed that the second nucleotide of the anticodon of the tRNA is posttranscriptionally changed to be recognized as an uridine residue. This restores the coding property of the tRNA. Direct sequencing as well as clones of the amplified cDNA indicated that about 50% of the cellular pool of pre-tRNA molecules for aspartic acid is edited. Thus, RNA editing occurs in mammalian mitochondria and can affect the anticodons of tRNAs.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1979 Apr 25;254(8):3067-73 - PubMed
    1. Science. 1993 Feb 5;259(5096):812-6 - PubMed
    1. Cell. 1986 Sep 12;46(6):819-26 - PubMed
    1. Anal Biochem. 1987 Apr;162(1):156-9 - PubMed
    1. Science. 1987 Oct 16;238(4825):363-6 - PubMed

Publication types