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Review
. 1993;100(4):293-306.
doi: 10.1159/000236429.

Pathogenic significance and diagnostic value of lupus autoantibodies

Y Tomer  1 , D Buskila, Y Shoenfeld
Affiliations
Review

Pathogenic significance and diagnostic value of lupus autoantibodies

Y Tomer et al. Int Arch Allergy Immunol. 1993.

Abstract

Systemic lupus erythematosus (SLE) is characterized by a panoply of autoantibodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

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