Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 May 1;53(9):1986-9.

Amplification of cyclin genes in colorectal carcinomas

F S Leach  1 , S J Elledge, C J Sherr, J K Willson, S Markowitz, K W Kinzler, B Vogelstein
Affiliations
  • PMID: 8481900

Amplification of cyclin genes in colorectal carcinomas

F S Leach et al. Cancer Res. .

Abstract

The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

PubMed Disclaimer

Publication types