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. 1977 Feb 28;37(2):177-81.
doi: 10.1007/BF00692065.

Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy

M Tomonaga

Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy

M Tomonaga. Acta Neuropathol. .

Abstract

Ultrastructure of neurofibrillary tangles was investigated on the subcortical neurons of an autopsy case of progressive supranuclear palsy. The patient was a 64-year-old female and suffered from her illness for 9 years. Two kinds of ultrastructure were observed in the subcortical neurofibrillary tangles, i.e. that 150 A straight tubules and the 220 A twisted tubules. They appeared separately in each neuron and a transition between these two structures could not be remarked. Besides, a few particles with a paracrystalline hexagonal structure were observed in some subcortical neurons.

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