Regulation of immunity to Ostertagia ostertagi

Abstract

Knowledge of bovine immune response to ostertagiasis is important to understanding the mechanisms of innate and acquired immunity to this economically important helminth parasite that infects cattle worldwide. Infection causes both antibody and cellular immune responses. Evidence shows that Ostertagia possesses excretory-secretory (ES) molecules that may regulate immune cell responses that affect acquired immunity and pathophysiological changes to infection. Ostertagia can down-regulate antibody and cellular immune responses. One of these ES regulatory molecules is a lectin that causes eosinophil chemotaxis. In addition to its antigenicity, this regulatory molecule serves as a means of communication between the parasite and cells of the host immune system. It is suggested that, lacking this type of communication, Ostertagia infection may not be readily recognized by the host immune cells. A hypothesis is proposed for the mechanisms of acquired immunity to Type I ostertagiasis. Regulatory molecules of Ostertagia ES are suggested as suitable vaccine candidates.