Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Mar-Apr;21(2):85-95.
doi: 10.1007/BF02367604.

Signal analysis of noninvasive Xenon-133 cerebral blood flow measurements

J L Jaggi  1 , W D Obrist, A Noordergraaf
Affiliations

Signal analysis of noninvasive Xenon-133 cerebral blood flow measurements

J L Jaggi et al. Ann Biomed Eng. 1993 Mar-Apr.

Abstract

An anatomical model in conjunction with experimentally determined absorption data provides a framework to simulate signals as obtained from the noninvasive Xenon-133 cerebral blood flow technique. The contribution of individual tissue compartments to the total signal as well as the effect on the computed results were investigated under normal conditions. The introduction of physiological abnormalities into the model allowed the determination of sensitivity of the technique with respect to size, position, and perfusion level of the lesion. In addition, effects of cross-talk between hemispheres and signal overlap of adjacent detectors were quantified. It was found that the change of externally measured blood flow is proportional to the decrement/increment of flow in the lesion. Contrary to earlier reports, the effects of cross-talk and signal overlap were not found to be serious limitations in identifying lesions.

PubMed Disclaimer

References

    1. Stroke. 1990 Nov;21(11):1555-61 - PubMed
    1. Circ Res. 1967 Jan;20(1):124-35 - PubMed
    1. Eur J Nucl Med. 1984;9(1):1-5 - PubMed
    1. Pharmacol Rev. 1951 Mar;3(1):1-41 - PubMed
    1. Cerebrovasc Brain Metab Rev. 1990 Winter;2(4):283-327 - PubMed

Substances