Case Reports
doi: 10.1016/0002-9394(77)90735-8.
Mitochondrial abnormalities in progressive external ophthalmoplegia
- PMID: 848542
- DOI: 10.1016/0002-9394(77)90735-8
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Case Reports
Mitochondrial abnormalities in progressive external ophthalmoplegia
Am J Ophthalmol.
1977 Mar.
Abstract
Three cases of chronic progressive external ophthalmoplegia demonstrated ragged-red fibers. Histochemical stains showed that the ragged-red fiber appearance was produced by abnormal mitochondria in the muscle. Electron microscopic studies demonstrated the ultrastructural origin of the intramitochondrial inclusions seen in ragged-red fibers. The associated abnormalities in lactic acid metabolism possibly represent an underlying generalized defect in metabolism. This evidence suggests that chronic progressive external ophthalmoplegia is a diffuse disease of the mitochondria.
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