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Review
. 1993 Feb 19;15(1):2-9.
doi: 10.1007/BF02116163.

Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system

J B Van Bree  1 , A G De Boer, M Danhof, D D Breimer
Affiliations
Review

Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system

J B Van Bree et al. Pharm World Sci. .

Abstract

This is the third part of a review on the transport of drugs across the blood-brain barrier. In the first two parts, the anatomical and physiological aspects and the various techniques that can be used to study blood-brain transport have been discussed and reviewed. This third part focuses specifically on the mechanisms that are involved in drug transport across the blood-brain barrier. In addition, the opportunities to improve drug transport into the brain will be reviewed. Emphasis is on the transport of peptides.

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