Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Mar;3(3):229-34.
doi: 10.1038/ng0393-229.

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

G Bajocchi  1 , S H Feldman, R G Crystal, A Mastrangeli
Affiliations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

G Bajocchi et al. Nat Genet. 1993 Mar.

Abstract

To evaluate the potential for adenovirus-mediated central nervous system (CNS) gene transfer, the replication deficient recombinant adenovirus vectors Ad.RSV beta gal (coding for beta-galactosidase) and Ad-alpha 1AT (coding for human alpha 1-antitrypsin) were administered to the lateral ventricle of rats. Ad.RSV beta gal transferred beta-galactosidase to ependymal cells lining the ventricles whereas Ad-alpha 1AT mediated alpha 1-antitrypsin secretion into the cerebral spinal fluid for 1 week. These observations, together with beta-galactosidase activity in the globus pallidus and substantia nigra following stereotactic administration of Ad.RSV beta gal to the globus pallidus, suggest that adenovirus vectors will be useful for CNS gene therapy.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources