Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
- PMID: 8485578
- DOI: 10.1038/ng0393-229
Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
Abstract
To evaluate the potential for adenovirus-mediated central nervous system (CNS) gene transfer, the replication deficient recombinant adenovirus vectors Ad.RSV beta gal (coding for beta-galactosidase) and Ad-alpha 1AT (coding for human alpha 1-antitrypsin) were administered to the lateral ventricle of rats. Ad.RSV beta gal transferred beta-galactosidase to ependymal cells lining the ventricles whereas Ad-alpha 1AT mediated alpha 1-antitrypsin secretion into the cerebral spinal fluid for 1 week. These observations, together with beta-galactosidase activity in the globus pallidus and substantia nigra following stereotactic administration of Ad.RSV beta gal to the globus pallidus, suggest that adenovirus vectors will be useful for CNS gene therapy.
Comment in
-
Gene delivery into the brain using virus vectors.Nat Genet. 1993 Mar;3(3):187-9. doi: 10.1038/ng0393-187. Nat Genet. 1993. PMID: 8485570 No abstract available.
Similar articles
-
Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.J Clin Invest. 1993 Jan;91(1):225-34. doi: 10.1172/JCI116175. J Clin Invest. 1993. PMID: 8423221 Free PMC article.
-
Adenovirus-mediated in vivo gene transfer and expression in normal rat liver.Nat Genet. 1992 Aug;1(5):372-8. doi: 10.1038/ng0892-372. Nat Genet. 1992. PMID: 1302034
-
Transfer of a foreign gene into the brain using adenovirus vectors.Nat Genet. 1993 Mar;3(3):224-8. doi: 10.1038/ng0393-224. Nat Genet. 1993. PMID: 8485577
-
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.Hum Gene Ther. 1994 Apr;5(4):437-47. doi: 10.1089/hum.1994.5.4-437. Hum Gene Ther. 1994. PMID: 7519451
-
Intraperitoneal in vivo gene therapy to deliver alpha 1-antitrypsin to the systemic circulation.Am J Respir Cell Mol Biol. 1994 Apr;10(4):369-77. doi: 10.1165/ajrcmb.10.4.8136153. Am J Respir Cell Mol Biol. 1994. PMID: 8136153
Cited by
-
Retargeted adenoviruses for radiation-guided gene delivery.Cancer Gene Ther. 2016 Sep;23(9):303-14. doi: 10.1038/cgt.2016.32. Epub 2016 Aug 5. Cancer Gene Ther. 2016. PMID: 27492853 Free PMC article.
-
Gene therapy in pediatric oncology.Invest New Drugs. 1996;14(1):87-99. doi: 10.1007/BF00173685. Invest New Drugs. 1996. PMID: 8880396 Review.
-
Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid.Brain Res. 2010 Nov 4;1359:1-13. doi: 10.1016/j.brainres.2010.08.044. Epub 2010 Aug 21. Brain Res. 2010. PMID: 20732308 Free PMC article.
-
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector.J Virol. 1997 Sep;71(9):6641-9. doi: 10.1128/JVI.71.9.6641-6649.1997. J Virol. 1997. PMID: 9261386 Free PMC article.
-
Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12547-52. doi: 10.1073/pnas.93.22.12547. Proc Natl Acad Sci U S A. 1996. PMID: 8901619 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
