Review
doi: 10.3109/07357909309024857.
Mechanisms by which interferon potentiates chemotherapy
Affiliations
- PMID: 8485653
- DOI: 10.3109/07357909309024857
Item in Clipboard
Review
Mechanisms by which interferon potentiates chemotherapy
Cancer Invest.
1993.
Abstract
IFNs potentiate the activity of multiple chemotherapy drugs in vitro; improved activity has been noted with 5-FU and IFN-alpha against colon carcinoma and with IFN-alpha and DTIC against melanoma. The mechanisms whereby interferon potentiates the activity of chemotherapeutic drugs are complex, and different mechanisms may be operative with different drugs and against different tumors. Both indirect immunoaugmentative effects of interferon and direct biochemical modulation of the drugs (as documented in detail with 5-FU) may play a role; further elucidation of these mechanisms will enable us to optimally utilize the combination of interferon and antineoplastic agents.
Similar articles
-
Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells.Eur J Cancer. 1997 Mar;33(3):471-8. doi: 10.1016/s0959-8049(97)89024-7. Eur J Cancer. 1997. PMID: 9155534
-
Biomodulation of 5-fluorouracil by interferon-alpha in human renal carcinoma cells: relationship to the expression of thymidine phosphorylase.Cancer Chemother Pharmacol. 1999;44(2):91-6. doi: 10.1007/s002800050951. Cancer Chemother Pharmacol. 1999. PMID: 10412941
-
PTK787/ZK222584 combined with interferon alpha and 5-fluorouracil synergistically inhibits VEGF signaling pathway in hepatocellular carcinoma.Ann Surg Oncol. 2013 Dec;20 Suppl 3:S517-26. doi: 10.1245/s10434-013-2948-z. Epub 2013 Mar 19. Ann Surg Oncol. 2013. PMID: 23508585
-
The role of interferon-alpha as a modulator of fluorouracil and leucovorin.Eur J Cancer. 1995 Jul-Aug;31A(7-8):1316-20. doi: 10.1016/0959-8049(95)91267-g. Eur J Cancer. 1995. PMID: 7577043 Review.
-
Biochemical modulation of 5-fluorouracil by folinic acid or alpha-interferon with and without other cytostatic drugs in gastric, esophageal, and pancreatic cancer.Semin Oncol. 1992 Apr;19(2 Suppl 3):215-9. Semin Oncol. 1992. PMID: 1557651 Review.
Cited by
-
Active vs. passive resistance, dose-response relationships, high dose chemotherapy, and resistance modulation: a hypothesis.Invest New Drugs. 1996;14(2):115-30. doi: 10.1007/BF00210782. Invest New Drugs. 1996. PMID: 8913832 Review.
-
IL-2-mediated augmentation of NK-cell activity and activation antigen expression on NK- and T-cell subsets in patients with metastatic melanoma treated with interferon-alpha and DTIC.Clin Exp Metastasis. 2003;20(7):647-55. doi: 10.1023/a:1027387930868. Clin Exp Metastasis. 2003. PMID: 14669796
-
A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction).Cancer Metastasis Rev. 1996 Jun;15(2):247-72. doi: 10.1007/BF00437479. Cancer Metastasis Rev. 1996. PMID: 8842498 Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
