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. 1977 Feb;11(2):244-7.
doi: 10.1128/AAC.11.2.244.

Bone marrow toxicity associated with 5-fluorocytosine therapy

C A Kauffman, P T Frame

Bone marrow toxicity associated with 5-fluorocytosine therapy

C A Kauffman et al. Antimicrob Agents Chemother. 1977 Feb.

Abstract

Bone marrow toxicity occurred in 4 of 15 patients treated with 5-fluorocytosine (5-FC) for serious fungal infections. The development of marrow toxicity appeared to be related to serum 5-FC levels of 125 mug/ml or greater. In three patients, accumulation of toxic levels of 5-FC was related to diminished renal function. One patient with acute renal failure and prolonged high levels of 5-FC developed marrow aplasia and died of bacterial sepsis. Three patients experienced leukopenia, which was readily reversed when the dosage of 5-FC was decreased and the serum concentration was lowered. With careful monitoring of serum 5-FC concentration and renal function, the dose-related toxic effects of 5-FC on the marrow can be avoided.

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