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Case Reports
. 1977 Feb;11(2):369-71.
doi: 10.1128/AAC.11.2.369.

Antimicrobial activity of cefamandole against Salmonella typhi

S Z Hirschman, B R Meyers, A Miller
Case Reports

Antimicrobial activity of cefamandole against Salmonella typhi

S Z Hirschman et al. Antimicrob Agents Chemother. 1977 Feb.

Abstract

A patient with Salmonella typhi bacteremia was sucessfully treated with cefamandole, a new cephalosporin derivative. Infection has not recurred during 6 months of follow-up observation. Minimum inhibitory concentrations and minimum bactericidal concentrations of cefamandole, cephalothin, ampicillin, and chloramphenicol were compared against 26 strains of S. typhi. All the strains were susceptible to cefamandole in vitro. Seven of the strains were resistant to chloramphenicol, and another seven were resistant to both chloramphenicol and ampicillin. Cefamandole appears to warrant further clinical trial for the treatment of typhoid fever.

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References

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