Comparative Study
The action of serotonin on basal gastric secretion in the conscious rat after intraventricular and intraperitoneal administration
- PMID: 849062
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Comparative Study
The action of serotonin on basal gastric secretion in the conscious rat after intraventricular and intraperitoneal administration
Arch Int Pharmacodyn Ther.
1977 Jan.
Abstract
In unanesthetized rats with chronic gastric fistulas the effect of various doses of 5-HT and atropine given intraperitoneally (i.p.) or into the lateral cerebral ventricle (i.c.) on basal gastric secretion was investigated. 5-HT given i.e. reduced HCl secretion more strongly than by the i.p. route. Atropine reduced gastric secretion equally after i.p. or i.e. administration. 5-HT given i.p. or i.c. produced a weaker inhibitory effect on basal gastric acid secretion than atropine. The stronger antisecretory action of 5-HT after i.c. than after i.p. administration indicates that the amine directly depresses the vegetative brain centers responsible for the basal secretory activity of the gastric mucosa.
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