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. 1993 Apr;20(4):302-7.
doi: 10.1007/BF00169805.

Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation

C Cotsyfakis  1 , A D Varvarigou, M Papadopoulos, S Stathaki, C I Stassinopoulou, E Chiotellis
Affiliations

Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation

C Cotsyfakis et al. Eur J Nucl Med. 1993 Apr.

Abstract

In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.

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