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. 1977 Feb;15(1-2):123-35.
doi: 10.1007/BF00484555.

Relationship between enzyme heterozygosity and quaternary structure

R D Ward

Relationship between enzyme heterozygosity and quaternary structure

R D Ward. Biochem Genet. 1977 Feb.

Abstract

The need for proteins to maintain particular quarternary structures constrains variability in amino acid sequence. Monomeric enzymes are then expected to be more variable than dimeric forms, which in turn are expected to be more variable than tetrameric forms. These predictions are confirmed by analysis of available data on enzyme variation. Theories relating enzyme heterozygosity to metabolic function are discussed in the light of these findings.

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