Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Feb;15(1-2):195-210.
doi: 10.1007/BF00484561.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. VI. Enzymatic studies of two mutants unable to convert inosinic acid to adenylic acid

A S Tu, D Patterson

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. VI. Enzymatic studies of two mutants unable to convert inosinic acid to adenylic acid

A S Tu et al. Biochem Genet. 1977 Feb.

Abstract

Ade-H and ade-I are two auxotrophic mutants of Chinese hamster ovary (CHO-K1) cells which specifically require adenine as the purine source to grow. The enzymatic defects of these mutants were examined in cell-free extracts. It was found that ade-H did not have any detectable adenylosuccinate synthetase activity and ade-I was defective in the adenylosuccinate lyase enzyme. The relevance of adenine-requiring mutants to the study of the regulation of purine metabolism in mammalian cells is discussed.

PubMed Disclaimer

References

    1. Somatic Cell Genet. 1976 May;2(3):189-203 - PubMed
    1. Cell. 1974 May;2(1):37-41 - PubMed
    1. J Biol Chem. 1962 Jun;237:1937-40 - PubMed
    1. J Biol Chem. 1971 Sep 25;246(18):5812-6 - PubMed
    1. J Biol Chem. 1972 Sep 10;247(17):5477-85 - PubMed

Publication types

LinkOut - more resources