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. 1977 Feb;15(1-2):31-46.
doi: 10.1007/BF00484546.

A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver

M Dizik, R W Elliott

A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver

M Dizik et al. Biochem Genet. 1977 Feb.

Abstract

Organ-specific electrophoretic heterogeneity of lysosomal alpha-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal alpha-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.

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