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Review
. 1993 Mar;12(5-6):425-31.
doi: 10.1002/sim.4780120505.

The NHLBI model: a 25 year history

L Friedman  1
Affiliations
Review

The NHLBI model: a 25 year history

L Friedman. Stat Med. 1993 Mar.

Abstract

Although newer techniques and procedures have been developed, many of the clinical trial design and monitoring concepts used today in the NHLBI were implemented 25 years ago. Among these are the organizational structure of multicentre trials and the use of an independent data monitoring committee. Examples of data monitoring committee discussions and decisions are provided.

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