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Comparative Study
. 1993 Feb;41(2):193-201.
doi: 10.1016/0166-0934(93)90126-c.

Comparative analysis of scrapie agent inactivation methods

D R Ernst  1 , R E Race
Affiliations
Comparative Study

Comparative analysis of scrapie agent inactivation methods

D R Ernst et al. J Virol Methods. 1993 Feb.

Abstract

A scrapie-infected hamster brain homogenate was subjected to several different potential inactivation methods. Methods included autoclaving for various lengths of time, either alone or in combination with different concentrations of sodium hydroxide or LpH, an aqueous acid phenolic derivative (Calgon Vestal Laboratories in St. Louis, MO). Inactivation treatments utilizing either NaOH or LpH alone were also evaluated. It was determined that several of the treatments inactivated all of the detectable infectivity.

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