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Comparative Study
. 1993 Jun;67(6):3649-52.
doi: 10.1128/JVI.67.6.3649-3652.1993.

A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism

M T Boyd  1 , G R Simpson, A J Cann, M A Johnson, R A Weiss
Affiliations
Comparative Study

A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism

M T Boyd et al. J Virol. 1993 Jun.

Abstract

Specific point mutations which affect viral tropism have been identified in both the V3 loop and in the CD4-binding region of the human immunodeficiency virus type 1 surface glycoprotein gp120. Here we report that a single point mutation in the first variable region (V1) of human immunodeficiency virus type 1 strain JRCSF is responsible for a change in viral tropism.

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References

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