Review
doi: 10.1016/0167-5699(93)90283-q.
The roles of CD8 in cytotoxic T lymphocyte function
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- PMID: 8499079
- DOI: 10.1016/0167-5699(93)90283-q
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Review
The roles of CD8 in cytotoxic T lymphocyte function
Immunol Today.
1993 Apr.
Abstract
The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.
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