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. 1993 May;91(4):403-4.
doi: 10.1007/BF00217368.

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

J K Tarlow  1 , A I Blakemore, A Lennard, R Solari, H N Hughes, A Steinkasserer, G W Duff
Affiliations

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

J K Tarlow et al. Hum Genet. 1993 May.

Abstract

We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist gene and identified two new alleles of the system. We have shown that the polymorphism is caused by the variable copy number of an 86-bp sequence, by using the polymerase chain reaction and primers immediately flanking the repeat region, and by direct sequencing. The repeat region contains three potential protein-binding sites and therefore the variable copy number may have functional significance.

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