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. 1977 Apr;201(1):1-7.

Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response

Y H Chang
  • PMID: 850133

Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response

Y H Chang. J Pharmacol Exp Ther. 1977 Apr.

Abstract

A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.

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