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Clinical Trial
. 1993 Jun;149(6):1485-7.
doi: 10.1016/s0022-5347(17)36423-6.

Mitomycin C in combination with orchiectomy for newly diagnosed metastatic prostate cancer: preliminary results on a randomized trial

H Van Poppel  1 , F van den Broucke, J Derluyn, G Popelier, J Casselman, I Billiet, L van Uytsel, R Paridaens, L Baert
Affiliations
Clinical Trial

Mitomycin C in combination with orchiectomy for newly diagnosed metastatic prostate cancer: preliminary results on a randomized trial

H Van Poppel et al. J Urol. 1993 Jun.

Abstract

The preliminary results of a randomized trial comparing orchiectomy versus orchiectomy and mitomycin C in 119 newly diagnosed metastatic prostate cancer patients are presented. Of 109 evaluable patients 57 were treated with orchiectomy alone and 52 received adjuvant intravenous mitomycin C. Mean interval to progression was 13 months in the orchiectomy group versus 11 months in the mitomycin C group. Preliminary analysis did not demonstrate a favorable effect of the combination with this chemotherapeutic agent compared to orchiectomy alone (p = 0.3).

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