Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1993 Apr;3(2):232-7.
doi: 10.1016/0959-437x(93)90028-n.

Regulation of the beta-globin locus

M Crossley  1 , S H Orkin
Affiliations
Review

Regulation of the beta-globin locus

M Crossley et al. Curr Opin Genet Dev. 1993 Apr.

Abstract

Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region. Recent studies have provided new insights into how the individual genes of the cluster are regulated through development. The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.

PubMed Disclaimer

Publication types

LinkOut - more resources