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. 1993 Jun 7;324(1):51-5.
doi: 10.1016/0014-5793(93)81530-d.

Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene

Y Watanabe  1 , N Usada, H Minami, T Morita, S Tsugane, R Ishikawa, K Kohama, Y Tomida, H Hidaka
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Free article

Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene

Y Watanabe et al. FEBS Lett. .
Free article

Abstract

Cell transformations accompany alterations in cell morphology and microfilament patterns. Calvasculin encodes mRNA termed pEL-98, 18A2, 42A, p9Ka, or mts1, found to be elevated in several metastatic cell lines. We report the elevation of calvasculin expression in SR-3Y1 cells, which show disappearance of ordered microfilaments, compared to that in 3Y1 cells and that the similar distribution of calvasculin to that of actin filaments. Interestingly, calvasculin co-sediments with F-actin and bundles actin filaments in a Ca(2+)-dependent manner. This activity, along with the elevation of calvasculin following transformation, suggests that the disorganization of filaments in SR-3Y1 cell is due to the cross-linking activity of calvasculin.

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