Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 May 25;21(10):2415-21.
doi: 10.1093/nar/21.10.2415.

Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii

Y Liu  1 , M J Leibowitz
Affiliations
Free PMC article

Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii

Y Liu et al. Nucleic Acids Res. .
Free PMC article

Abstract

The sequences of the rRNA genes of Pneumocystis carinii from rat and human sources demonstrate three distinct genotypes based on the group I introns present in these genes. One rat isolate (Pc1) contains such introns in its 16S and 26S rRNA genes, while another rat isolate (Pc2) and a human isolate (Pc3) only contain an intron in the 26S rRNA gene. The four introns all catalyze their own excision from RNA transcripts, and this reaction is inhibited by the anti-pneumocystis drug pentamidine and its analogues. Although they differ in sequence, they are more similar to one another than to group I introns found in other eukaryotic microbes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1980 Jan;77(1):201-4 - PubMed
    1. Nature. 1988 Aug 11;334(6182):519-22 - PubMed
    1. Nature. 1983 Feb 17-23;301(5901):578-83 - PubMed
    1. Nucleic Acids Res. 1985 Oct 25;13(20):7445-55 - PubMed
    1. Cell. 1989 Feb 10;56(3):323-6 - PubMed

Publication types

Associated data