Control of the yeast cell cycle by the Cdc28 protein kinase

Abstract

It is becoming increasingly apparent that the diverse functions of Cdc28 during the yeast cell cycle are performed by forms of the kinase that are distinguished by their cyclin subunits. Entry into the cell cycle at START involves the Cln cyclins. S phase needs Clb5 or Clb6 B-type cyclins. Bipolar mitotic spindle formation involves Clb1-4 B-type cyclins. Much of the order and timing of the cell cycle events may involve the progressive activation of Cdc28 kinase activities associated with different cyclins, whose periodicity during the cycle is determined by both transcriptional and post-transcriptional controls.