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. 1993 Jun 15;81(12):3234-41.

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription

L I Zon  1 , Y Yamaguchi, K Yee, E A Albee, A Kimura, J C Bennett, S H Orkin, S J Ackerman
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  • PMID: 8507862
Free article

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription

L I Zon et al. Blood. .
Free article

Abstract

The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.

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