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Comparative Study
. 1993 Jun 14;324(2):219-25.
doi: 10.1016/0014-5793(93)81397-i.

Cloning and functional expression of a brain G-protein-coupled ATP receptor

T E Webb  1 , J Simon, B J Krishek, A N Bateson, T G Smart, B F King, G Burnstock, E A Barnard
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Free article
Comparative Study

Cloning and functional expression of a brain G-protein-coupled ATP receptor

T E Webb et al. FEBS Lett. .
Free article

Abstract

A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by hybridization screening. The encoded protein has a sequence of 362 amino acids (41 kDa) and shares no more than 27% amino acid identity with any known GCR. When expressed as a complementary RNA (cRNA) in Xenopus oocytes a slowly-developing inward current was observed in response to application of ATP. The pharmacology of this expressed protein defines it as a P2Y purinoceptor.

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