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. 1993 Jun;111(6):849-54.
doi: 10.1001/archopht.1993.01090060139038.

Pharmacologic induction of posterior vitreous detachment in the rabbit

T C Verstraeten  1 , C Chapman, M Hartzer, B S Winkler, M T Trese, G A Williams
Affiliations

Pharmacologic induction of posterior vitreous detachment in the rabbit

T C Verstraeten et al. Arch Ophthalmol. 1993 Jun.

Abstract

Objective: To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.

Methods: We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.

Results: In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.

Conclusion: Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.

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