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. 1993;44(4):381-2.
doi: 10.1007/BF00316477.

Studies on placental transfer of celiprolol

B Kofahl  1 , D Henke, A Hettenbach, E Mutschler
Affiliations

Studies on placental transfer of celiprolol

B Kofahl et al. Eur J Clin Pharmacol. 1993.

Abstract

The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers in the child. Therefore, in further investigations only the racemate needs to be determined.

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References

    1. J Chromatogr. 1989 Nov 24;496(2):387-96 - PubMed
    1. Am J Obstet Gynecol. 1988 Jul;159(1):42-7 - PubMed

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