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. 1993;12(1):1-11.
doi: 10.1007/BF02918364.

Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients

E Reed  1 , E Ho, D J Cohen, W Ramey, C Marboe, V D'Agati, E A Rose, M Hardy, N Suciu-Foca
Affiliations

Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients

E Reed et al. Immunol Res. 1993.

Abstract

Chronic rejection is the major threat to both heart and renal allograft survival. We have explored the possibility that some patients with anti-donor HLA antibodies (Ab1) develop specific anti-idiotypic antibodies (Ab2) which suppress the production of Ab1, and subsequently, the progression of chronic rejection. Analysis of Ab2 in sera obtained from Ab1 producers showed that 22% of heart and 18% of kidney recipients produced Ab2. The 4- and 5-year actuarial graft survivals in Ab2 producers were 100% and 83%, respectively, compared to 57% in patients who formed Ab1 but not Ab2 (p < 0.004). Patients carrying the DR2 alleles, DRB1*1501, *1502 or *1601 were at a lower risk of producing anti-donor HLA antibodies.

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