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. 1993 Feb;189(1):58-65.
doi: 10.1016/S0344-0338(11)80117-2.

AIDS-myelopathy. A neuropathological study

M Bergmann  1 , F Gullotta, K Kuchelmeister, T Masini, G Angeli
Affiliations

AIDS-myelopathy. A neuropathological study

M Bergmann et al. Pathol Res Pract. 1993 Feb.

Abstract

Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.

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References

    1. Artigas J, Grosse G, Niedobitek F. Vacuolar myelopathy in AIDS — a morphological analysis. Path Res Pract. 1990;186:228–237. - PubMed
    1. Artigas J, Grosse G, Habedank S, Heise W, Niedobitek F. Zur Morphologie vakuolärer Veränderungen des Rückenmarks bei AIDS-Patienten (vakuoläre Myelopathie) Pathologe. 1990;11:260–267. - PubMed
    1. Berger JR, Raffanti S, Svenningsson A, McCarthy M, Snodgrass S, Resnik L. The role of HTLV in HIV-1 neurologic disease. Neurology. 1991;41:197–202. - PubMed
    1. Budka H, Costanzi G, Cristina S, Lechi A, Parravicini C, Trabattoni R, Vago L. Brain pathology induced with the human immunodeficiency virus (HIV) Acta Neuropathol (Berl) 1987;75:185–198. - PubMed
    1. Budka H, Maier H, Pohl P. Human immunodeficiency virus in vacuolar myelopathy of the acquired immunodeficiency syndrome. N Engl J Med. 1988;319:1667–1668. - PubMed

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