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Review
. 1993 Jul;203(3):286-90.
doi: 10.3181/00379727-203-43600a.

Superoxide dismutase and pulmonary oxygen toxicity

M F Tsan  1
Affiliations
Review

Superoxide dismutase and pulmonary oxygen toxicity

M F Tsan. Proc Soc Exp Biol Med. 1993 Jul.

Erratum in

  • Proc Soc Exp Biol Med 1993 Sep;203(4):512

Abstract

Three forms of superoxide dismutase (SOD) exist in the lung: CuZnSOD, MnSOD and extracellular SOD. Evidence suggests that both CuZnSOD and MnSOD are important in pulmonary defense against oxygen toxicity. Enhancement of pulmonary levels of CuZnSOD by transgenic overexpression of CuZnSOD, or tracheal insufflation of liposome-encapsulated or polyethylene glycol-conjugated CuZnSOD, protects animals against oxygen toxicity. Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity. The role of extracellular SOD in the pulmonary defense against oxygen toxicity is not clear.

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