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. 1979 Mar 17;1(8116):578-80.
doi: 10.1016/s0140-6736(79)91006-7.

Evidence that Alzheimer neurofibrillary tangles originate from neurotubules

I Grundke-Iqbal, A B Johnson, H M Wisniewski, R D Terry, K Iqbal

Evidence that Alzheimer neurofibrillary tangles originate from neurotubules

I Grundke-Iqbal et al. Lancet. .

Abstract

Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in tissue sections by the peroxidase-antiperoxidase technique. These results indicate that neurofibrillary tangles in Alzheimer's disease probably originate from neurotubules.

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