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Review
. 1993 Apr;9(4):138-41.
doi: 10.1016/0168-9525(93)90209-z.

The multistep nature of cancer

B Vogelstein  1 , K W Kinzler
Affiliations
Review

The multistep nature of cancer

B Vogelstein et al. Trends Genet. 1993 Apr.

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

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