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. 1993;105(6):315-20.
doi: 10.1007/BF01222114.

Forensic validation of the STR systems SE 33 and TC 11

P Wiegand  1 , B Budowle, S Rand, B Brinkmann
Affiliations

Forensic validation of the STR systems SE 33 and TC 11

P Wiegand et al. Int J Legal Med. 1993.

Abstract

Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 - n = 21; TC 11 - n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

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