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Case Reports
. 1977 Apr;39(4):1535-41.
doi: 10.1002/1097-0142(197704)39:4<1535::aid-cncr2820390426>3.0.co;2-0.

Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland

E C Dooling, J G Chi, F H Gilles
Case Reports

Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland

E C Dooling et al. Cancer. 1977 Apr.

Abstract

Striking similarities between the pineals of 107 fetuses and infants and a pigmented neuroectodermal tumor occurring in the right orbital and right frontal regions in a 6-month-old Puerto Rican boy were found. Both the human fetal pineal and melanotic neuroectodermal tumors of infancy are characterized by pigmented (melanin) epithelial cells, small undifferentiated cells, and a fibrovascular stroma. Our findings suggest the fetal pineal may be a normally occurring precursor of the melanotic neuroectodermal tumor of infancy, or that melanin production may be a normal capability of differentiating neuroepithelial cells.

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