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Review
. 1995 Sep;3(9):351-6.
doi: 10.1016/s0966-842x(00)88974-x.

Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis

V Deretic  1 , M J Schurr, H Yu
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Review

Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis

V Deretic et al. Trends Microbiol. 1995 Sep.

Abstract

During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their accessory elements.

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