KSR, a novel protein kinase required for RAS signal transduction
- PMID: 8521512
- DOI: 10.1016/0092-8674(95)90204-x
KSR, a novel protein kinase required for RAS signal transduction
Abstract
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the beta subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that KSR functions in multiple receptor tyrosine kinase pathways. We have isolated mammalian homologs of KSR that, together with the Drosophila gene, define a novel class of kinases. Our results suggest that KSR is a general and evolutionarily conserved component of the RAS signaling pathway that acts between RAS and RAF.
Comment in
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KSR: a novel player in the RAS pathway.Cell. 1995 Dec 15;83(6):831-4. doi: 10.1016/0092-8674(95)90198-1. Cell. 1995. PMID: 8521506 Review. No abstract available.
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