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. 1995 Dec 7;378(6557):578-83.
doi: 10.1038/378578a0.

Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex

Y Zheng  1 , M L Wong, B Alberts, T Mitchison
Affiliations

Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex

Y Zheng et al. Nature. .

Abstract

The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.

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