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. 1977 Mar 11;11(3):199-201.
doi: 10.1007/BF00606410.

Clozapine-induced agranulocytosis: a situation report up to August 1976

B Anderman, R W Griffith

Clozapine-induced agranulocytosis: a situation report up to August 1976

B Anderman et al. Eur J Clin Pharmacol. .

Abstract

The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the "epidemic" in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measure (e.g. weekly blood counts) reduces the mortality-rate of this condition.

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