Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995:15:495-518.
doi: 10.1146/annurev.nu.15.070195.002431.

Apolipoprotein E and the apolipoprotein E-deficient mouse

A S Plump  1 , J L Breslow
Affiliations
Review

Apolipoprotein E and the apolipoprotein E-deficient mouse

A S Plump et al. Annu Rev Nutr. 1995.

Abstract

Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate this same genetic variation in determining susceptibility to Alzheimer's disease. An apoE-deficient mouse has been created to further understand the role of apoE in these areas. This review briefly discussed the biological and clinical importance of this protein and describes the early experiments performed in the apoE-deficient mouse.

PubMed Disclaimer