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. 1977;9(4):249-57.
doi: 10.1111/j.1399-3011.1977.tb03488.x.

Synthesis of N-acetyl-muramyl-L-alanyl-D-isoglutamine, an adjuvant of the immune response, and of some n-acetyl-muramyl-peptide analogs

P Lefrancier, J Choay, M Derrien, I Lederman

Synthesis of N-acetyl-muramyl-L-alanyl-D-isoglutamine, an adjuvant of the immune response, and of some n-acetyl-muramyl-peptide analogs

P Lefrancier et al. Int J Pept Protein Res. 1977.

Abstract

A relatively easy synthetic method is reported for the production of the immunoadjuvant glycopeptide, N-acetyl-muramy-L-alanyl-D-isoglutamine (MDP). Most of the details in this method were also applied to the preparation of some analogs, that were synthesized in order to study structure-activity relationships.

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